Endoscopic examination with iodine staining has led to the easy detect
ion of multiple superficial esophageal carcinoma (MSEC). The purpose o
f this study was to better understand the characteristics of MSEC. Of
49 patients with multiple esophageal carcinomas, 19 had superficial ca
rcinoma. Multiple esophageal carcinomas were more often found in super
ficial carcinomas (31.1%) than in advanced carcinomas (14.4%). Compari
ng the depth of invasion of multiple esophageal carcinomas, the second
ary lesions represented relatively early stages. Ki-67-positive cells
were seen significantly more frequently in the main lesion of MSEC tha
n in the secondary lesions, but proliferating cell nuclear antigen pos
itivity and p53 expression did not differ significantly. Since multipl
e carcinoma occurs more frequently, care should be taken to look for s
mall secondary lesions when treating superficial esophageal carcinoma.
Ki-67 immunohistochemistry suggested that tumor cells proliferate mor
e slowly in secondary lesions than in main lesions of MSEC.