CLINICOPATHOLOGICAL STUDY OF MULTIPLE PRIMARY SUPERFICIAL CARCINOMA OF THE ESOPHAGUS

Citation
T. Fujii et al., CLINICOPATHOLOGICAL STUDY OF MULTIPLE PRIMARY SUPERFICIAL CARCINOMA OF THE ESOPHAGUS, International journal of oncology, 12(2), 1998, pp. 421-425
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
1019-6439
Volume
12
Issue
2
Year of publication
1998
Pages
421 - 425
Database
ISI
SICI code
1019-6439(1998)12:2<421:CSOMPS>2.0.ZU;2-T
Abstract
Endoscopic examination with iodine staining has led to the easy detect ion of multiple superficial esophageal carcinoma (MSEC). The purpose o f this study was to better understand the characteristics of MSEC. Of 49 patients with multiple esophageal carcinomas, 19 had superficial ca rcinoma. Multiple esophageal carcinomas were more often found in super ficial carcinomas (31.1%) than in advanced carcinomas (14.4%). Compari ng the depth of invasion of multiple esophageal carcinomas, the second ary lesions represented relatively early stages. Ki-67-positive cells were seen significantly more frequently in the main lesion of MSEC tha n in the secondary lesions, but proliferating cell nuclear antigen pos itivity and p53 expression did not differ significantly. Since multipl e carcinoma occurs more frequently, care should be taken to look for s mall secondary lesions when treating superficial esophageal carcinoma. Ki-67 immunohistochemistry suggested that tumor cells proliferate mor e slowly in secondary lesions than in main lesions of MSEC.