EVALUATION OF 2 BIOLOGICAL MARKERS COMBINED AS A PARAMETER OF ALCOHOLDEPENDENCY

Citation
Ne. Huseby et al., EVALUATION OF 2 BIOLOGICAL MARKERS COMBINED AS A PARAMETER OF ALCOHOLDEPENDENCY, Alcohol and alcoholism, 32(6), 1997, pp. 731-737
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
32
Issue
6
Year of publication
1997
Pages
731 - 737
Database
ISI
SICI code
0735-0414(1997)32:6<731:EO2BMC>2.0.ZU;2-3
Abstract
A test was constructed by combining carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (GT) and was evaluated in detect ing alcohol-dependent patients in a surgical ward. The performance of the combined test was significantly better than that of either %CDT al one or GT alone, as evaluated by calculating sensitivity and likelihoo d ratio at a specificity of 0.85 and by comparing areas under receiver -operating characteristic curves statistically. Improved performance w as found for the whole group of patients, for men, for patients older than 35 years of age, and for those patients consuming more than 60 g alcohol per day. The performance of %CDT alone was similar to that of GT, %CDT being better in the age group 35-50 years, whereas GT was bet ter for those drinking less than 60 g per day and for the oldest patie nts (>50 years). Neither of the two tests or their combination perform ed well for patients younger than 36 years of age.