TUMOR CELL-ASSOCIATED HYALURONAN AS AN UNFAVORABLE PROGNOSTIC FACTOR IN COLORECTAL-CANCER

Citation
K. Ropponen et al., TUMOR CELL-ASSOCIATED HYALURONAN AS AN UNFAVORABLE PROGNOSTIC FACTOR IN COLORECTAL-CANCER, Cancer research, 58(2), 1998, pp. 342-347
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ISSN journal
0008-5472
Volume
58
Issue
2
Year of publication
1998
Pages
342 - 347
Database
ISI
SICI code
0008-5472(1998)58:2<342:TCHAAU>2.0.ZU;2-H
Abstract
Hyaluronan (HA) is a linear high molecular weight extracellular polysa ccharide. It is thought to be involved in mitosis and the enhancement of wound healing, tumor invasion, and metastasis. Because its clinical relevance in cancer has not been explored, we scored HA in colorectal adenocarcinoma and studied its relationship with patient survival, A specific probe prepared from cartilage proteoglycan aggregates was use d to stain paraffin-embedded tumor samples from 202 colorectal adenoca rcinoma patients treated in Kuopio University Hospital and followed up for a mean of 14 years, The hypothesis that the percentage of HA-posi tive carcinoma cells (HA%) and HA intensity in cancer cells correlated with survival was tested with the log-rank test, hazard ratios, and t heir confidence intervals, Ninety-three % of tumors had at least a pro portion of carcinoma cells positive for HA. HA intensity in tumor epit helium was stronger in Dukes' stages C and D tumors and in high-grade tumors. The cancer-related survival rate was lower among patients with strong HA intensity in tumor epithelium (P < 0.001) and high HA% (P < 0.001), Recurrence-free survival was also shorter in patients with an intense signal for HA (P = 0.001) and high HA% in tumor epithelium (P = 0.04). HA intensity in tumor epithelium independently predicted sur vival and recurrence-free survival (Cox's analysis), We conclude that a high proportion of HA-positive cancer cells and high intensity of th e HA-signal predicts a poor survival rate, The abnormal expression of HA in the neoplastic colon epithelial cells is suggested to provide a distinct advantage for invasive growth and metastasis.