EFFECTS OF UNSATURATED FATTY-ACIDS ON INTERLEUKIN-1-BETA PRODUCTION BY HUMAN MONOCYTES

Citation
D. Rothman et al., EFFECTS OF UNSATURATED FATTY-ACIDS ON INTERLEUKIN-1-BETA PRODUCTION BY HUMAN MONOCYTES, Cytokine, 9(12), 1997, pp. 1008-1012
Citations number
13
Language
INGLESE
art.tipo
Article
Journal title
ISSN journal
1043-4666
Volume
9
Issue
12
Year of publication
1997
Pages
1008 - 1012
Database
ISI
SICI code
1043-4666(1997)9:12<1008:EOUFOI>2.0.ZU;2-M
Abstract
Dihomogammalinolenic acid is derived from gammalinolenic acid, adminis tration of which suppresses joint inflammation. It is reported here th at interleukin 1 beta (IL-1 beta) production by human monocytes is enh anced markedly when cells are incubated 18-24 h with the polyunsaturat ed fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid ( AA), then stimulated with lipopolysaccharide, Effects of eicosapentaen oic acid (EPA) on IL-1 beta production are minimal, and palmitic acid (PA) does not influence IL-1 beta production. (C) 1996 Academic Press Limited.