LOW-DOSE ASPIRIN DECREASES BLOOD-ALCOHOL CONCENTRATIONS BY DELAYING GASTRIC-EMPTYING

Citation
S. Kechagias et al., LOW-DOSE ASPIRIN DECREASES BLOOD-ALCOHOL CONCENTRATIONS BY DELAYING GASTRIC-EMPTYING, European Journal of Clinical Pharmacology, 53(3-4), 1997, pp. 241-246
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0031-6970
Volume
53
Issue
3-4
Year of publication
1997
Pages
241 - 246
Database
ISI
SICI code
0031-6970(1997)53:3-4<241:LADBCB>2.0.ZU;2-X
Abstract
Objective: To determine if treatment with low-dose aspirin (ASA) influ ences the bioavailability of orally administered alcohol and to assess whether this is caused by altered gastric emptying as measured by the paracetamol absorption test. Methods: In a single-center controlled c rossover trial, ten healthy male medical students, aged 20-27 years, p articipated in two experiments in random order. Both times they took p aracetamol (1.5 g together with a standardized breakfast) and drank et hanol (0.3 g/kg) 1 h after eating breakfast. On one drinking occasion, no previous medication was given. The other alcohol session was perfo rmed after the subjects had taken 75 mg ASA once daily for 7 days. On both occasions, venous blood samples were obtained at exactly timed in tervals for a period of 3.5 h. Results: The blood-ethanol profiles sho wed large interindividual variations for both experiments. After treat ment with ASA, the maximum blood-ethanol concentration was distinctly lower in seven subjects, almost unchanged in two subjects and increase d in one subject. Overall, a statistically significant decrease in the peak blood-ethanol concentration was observed. Tile time required to reach peak blood-ethanol levels was somewhat longer after treatment wi th ASA. Although the areas under the concentration-time profiles were smaller after ASA treatment, these differences were not statistically significant. The concentrations of paracetamol in plasma were lower wh en ethanol was ingested after treatment with ASA and the areas under t he concentration-time curves (0-170 min) were smaller. Conclusions: In take of low-dose ASA (75 mg daily) tends to delay the absorption of a moderate dose of ethanol, which results in lower peak blood-ethanol co ncentrations and smaller areas under the concentration-time curves. Th e underlying mechanism seems to be delayed gastric emptying as indicat ed by the paracetamol absorption test.