MARKERS OF ACTIVATED COAGULATION FOR EARLY DIAGNOSIS OF ACUTE MYOCARDIAL-INFARCTION

Citation
J. Mair et al., MARKERS OF ACTIVATED COAGULATION FOR EARLY DIAGNOSIS OF ACUTE MYOCARDIAL-INFARCTION, Clinica chimica acta, 267(2), 1997, pp. 239-245
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Laboratory Technology",Biology
Journal title
ISSN journal
0009-8981
Volume
267
Issue
2
Year of publication
1997
Pages
239 - 245
Database
ISI
SICI code
0009-8981(1997)267:2<239:MOACFE>2.0.ZU;2-G
Abstract
Intracoronary thrombosis plays a key role in the pathogenesis of acute myocardial infarction (AMI), and the formation of an occlusive thromb us usually precedes the development of myocardial damage. Therefore we evaluated and compared the early sensitivities of thrombin-antithromb in III complex (TAT), D-dimer, myoglobin, creatine kinase (CK) MB mass concentration, and cardiac troponin T (cTnT) on admission to a corona ry care unit (CCU) before heparin or thrombolytic therapy was started. We investigated 31 consecutive patients admitted to CCU for evolving AMI within 6 hours from the onset of infarct-related symptoms; the med ian delay from chest pain onset to CCU admission was 135 minutes. Of a ll biochemical markers tested TAT had the highest early sensitivity on admission to the CCU, and TAT was significantly more sensitive than c TnT, CKMB mass, myoglobin, and D-dimer. However, TAT increases give no information about the location of clot formation in the body, and the diagnosis of AMI must be subsequently verified by an increase in more cardiacspecific proteins, such as troponins or CKMB. (C) 1997 Elsevie r Science B.V.