MICROTUBULE POLYMERIZATION DYNAMICS

Citation
A. Desai et Tj. Mitchison, MICROTUBULE POLYMERIZATION DYNAMICS, Annual review of cell and developmental biology, 13, 1997, pp. 83-117
Citations number
186
Language
INGLESE
art.tipo
Review
ISSN journal
1081-0706
Volume
13
Year of publication
1997
Pages
83 - 117
Database
ISI
SICI code
1081-0706(1997)13:<83:MPD>2.0.ZU;2-F
Abstract
The polymerization dynamics of microtubules are central to their biolo gical functions. Polymerization dynamics allow microtubules to adopt s patial arrangements that can change rapidly in response to cellular ne eds and, in some cases, to perform mechanical work. Microtubules utili ze the energy of GTP hydrolysis to fuel a unique polymerization mechan ism termed dynamic instability, In this review, we first describe prog ress toward understanding the mechanism of dynamic instability of pure tubulin and then discuss the function and regulation of microtubule d ynamic instability in living cells.