GENETICS OF TRANSCRIPTIONAL REGULATION IN YEAST - CONNECTIONS TO THE RNA-POLYMERASE-II CTD

Authors
Citation
M. Carlson, GENETICS OF TRANSCRIPTIONAL REGULATION IN YEAST - CONNECTIONS TO THE RNA-POLYMERASE-II CTD, Annual review of cell and developmental biology, 13, 1997, pp. 1-23
Citations number
105
Language
INGLESE
art.tipo
Review
ISSN journal
1081-0706
Volume
13
Year of publication
1997
Pages
1 - 23
Database
ISI
SICI code
1081-0706(1997)13:<1:GOTRIY>2.0.ZU;2-U
Abstract
Transcriptional regulation is important in all eukaryotic organisms fo r cell growth, development, and responses to environmental change. Sac charomyces cerevisiae, or bakers' yeast, has provided a powerful syste m for genetic analysis of transcriptional regulation, and findings fro m the study of this model system have proven broadly applicable to hig her organisms. Transcriptional regulation requires the interactions of regulatory proteins with various components of the transcription mach inery. Recently, genetic analysis of a diverse set of transcriptional regulatory responses has converged with studies of the function of the RNA polymerase II carboxy-terminal domain (CTD) to reveal regulatory roles for proteins associated with the CTD. These proteins, designated Srb/mediator proteins, are broadly involved in both positive and nega tive regulatory responses in vivo. This review focuses on the connecti ons between genetic analysis of transcriptional regulation and the fun ctions of the Srb/mediator proteins associated with the RNA polymerase II CTD.