THE EFFECT OF BCG GENE ON ANTIGEN PRESENTATION OF SPLEEN ADHERENT CELLS AND PERITONEAL-MACROPHAGES FROM MYCOBACTERIUM-BOVIS BCG-INFECTED BCG(S) AND BCG(R) MICE
Dl. Xu et al., THE EFFECT OF BCG GENE ON ANTIGEN PRESENTATION OF SPLEEN ADHERENT CELLS AND PERITONEAL-MACROPHAGES FROM MYCOBACTERIUM-BOVIS BCG-INFECTED BCG(S) AND BCG(R) MICE, Veterinary microbiology, 59(1), 1997, pp. 67-78
To determine the role of the Beg gene in the resistance and susceptibi
lity of BCG-infected C57BL/6 (Bcg(s)) and its Bcg(r) congenic mice, th
e antigen presenting ability of spleen adherent cells and peritoneal m
acrophages, delayed type hypersensitivity (DTH) and lymphocyte blastog
enic responses were investigated. The results obtained indicate that t
he DTH and lymphocyte blastogenic responses in Bcg(r) congenic mice we
re higher than in the Beg s mice. Stimulation of spleen adherent cells
with live Mycobacterium bovis BCG or PPD-BCG resulted in a higher ant
igen presenting ability in Bcg(r) than in Bcg(s) mice. However, compar
atively low responses were associated with M. avium stimulation, with
those in Bcg(r) being higher than in Bcg(s). I-A expression was also c
omparatively higher in Bcg(r) than in Bcg(s) mice. This study demonstr
ates that the Beg gene seems to exhibit some effect on the antigen pre
senting ability of macrophages in immune responses of the congenic mic
e. (C) 1997 Elsevier Science B.V.