THE EFFECT OF BCG GENE ON ANTIGEN PRESENTATION OF SPLEEN ADHERENT CELLS AND PERITONEAL-MACROPHAGES FROM MYCOBACTERIUM-BOVIS BCG-INFECTED BCG(S) AND BCG(R) MICE

Citation
Dl. Xu et al., THE EFFECT OF BCG GENE ON ANTIGEN PRESENTATION OF SPLEEN ADHERENT CELLS AND PERITONEAL-MACROPHAGES FROM MYCOBACTERIUM-BOVIS BCG-INFECTED BCG(S) AND BCG(R) MICE, Veterinary microbiology, 59(1), 1997, pp. 67-78
Citations number
37
Language
INGLESE
art.tipo
Article
Journal title
ISSN journal
0378-1135
Volume
59
Issue
1
Year of publication
1997
Pages
67 - 78
Database
ISI
SICI code
0378-1135(1997)59:1<67:TEOBGO>2.0.ZU;2-K
Abstract
To determine the role of the Beg gene in the resistance and susceptibi lity of BCG-infected C57BL/6 (Bcg(s)) and its Bcg(r) congenic mice, th e antigen presenting ability of spleen adherent cells and peritoneal m acrophages, delayed type hypersensitivity (DTH) and lymphocyte blastog enic responses were investigated. The results obtained indicate that t he DTH and lymphocyte blastogenic responses in Bcg(r) congenic mice we re higher than in the Beg s mice. Stimulation of spleen adherent cells with live Mycobacterium bovis BCG or PPD-BCG resulted in a higher ant igen presenting ability in Bcg(r) than in Bcg(s) mice. However, compar atively low responses were associated with M. avium stimulation, with those in Bcg(r) being higher than in Bcg(s). I-A expression was also c omparatively higher in Bcg(r) than in Bcg(s) mice. This study demonstr ates that the Beg gene seems to exhibit some effect on the antigen pre senting ability of macrophages in immune responses of the congenic mic e. (C) 1997 Elsevier Science B.V.