SOURCE OF EXTRACELLULAR BRAIN ADENOSINE DURING HYPOXIA IN FETAL SHEEP

Citation
Bj. Koos et al., SOURCE OF EXTRACELLULAR BRAIN ADENOSINE DURING HYPOXIA IN FETAL SHEEP, Brain research, 778(2), 1997, pp. 439-442
Citations number
17
Language
INGLESE
art.tipo
Article
Journal title
ISSN journal
0006-8993
Volume
778
Issue
2
Year of publication
1997
Pages
439 - 442
Database
ISI
SICI code
0006-8993(1997)778:2<439:SOEBAD>2.0.ZU;2-2
Abstract
Microdialysis was performed to determine whether hypoxia increases fet al brain adenosine (ADO) concentration through dephosphorylation of ex tracellular 5'-adenosine monophosphate (5-AMP). Hypoxia(fetal PaO2, ap proximate to 14 Torr) increased fetal brain ADO levels similar to two- fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto-5'-nucleotidase (AOPCP). The hyp oxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'-AMP. (C) 1997 Elsevier Scienc e B.V.