ORAL HAIRY LEUKOPLAKIA - CLINICOPATHOLOGICAL FEATURES, PATHOGENESIS, DIAGNOSIS, AND CLINICAL-SIGNIFICANCE

Citation
D. Triantos et al., ORAL HAIRY LEUKOPLAKIA - CLINICOPATHOLOGICAL FEATURES, PATHOGENESIS, DIAGNOSIS, AND CLINICAL-SIGNIFICANCE, Clinical infectious diseases, 25(6), 1997, pp. 1392-1396
Citations number
50
Language
INGLESE
art.tipo
Article
ISSN journal
1058-4838
Volume
25
Issue
6
Year of publication
1997
Pages
1392 - 1396
Database
ISI
SICI code
1058-4838(1997)25:6<1392:OHL-CF>2.0.ZU;2-C
Abstract
Oral hairy leukoplakia (OHL) is a lesion frequently, although not excl usively, observed in patients infected by human immunodeficiency virus es (HIV)). OHL is clinically characterized by bilateral, often elevate d, white patches of the lateral borders and dorsum of the tongue. Hist ologically, there is profound acanthosis, sometimes with koilocytic ch anges, and a lack of a notable inflammatory infiltrate, The koilocytic changes are due to intense replication of Epstein-Barr virus (EBV), w hile epithelial hyperplasia and acanthosis are likely to result from t he combined action of the EBV-encoded proteins, latent membrane protei n-1, and antiapoptotic BHRF1. How OHL is initiated and whether it deve lops after EBV reactivation from latency or superinfection remain unre solved; nevertheless, definitive diagnosis requires the demonstration of EBV replicating vegetatively in histological or cytological specime ns, In patients with HIV infection, the development of OHL may herald severe HIV disease and the rapid onset of AIDS, but despite its title, OHL is not regarded as premalignant and is unlikely to give rise to o ral squamous cell carcinoma.