ADMINISTRATION OF COMBINED DIPHTHERIA AND TETANUS TOXOIDS AND PERTUSSIS-VACCINE, HEPATITIS-B VACCINE, AND HAEMOPHILUS-INFLUENZAE TYPE-B (HIB) VACCINE TO INFANTS AND RESPONSE TO A BOOSTER DOSE OF HIB CONJUGATE VACCINE

Citation
Me. Pichichero et S. Passador, ADMINISTRATION OF COMBINED DIPHTHERIA AND TETANUS TOXOIDS AND PERTUSSIS-VACCINE, HEPATITIS-B VACCINE, AND HAEMOPHILUS-INFLUENZAE TYPE-B (HIB) VACCINE TO INFANTS AND RESPONSE TO A BOOSTER DOSE OF HIB CONJUGATE VACCINE, Clinical infectious diseases, 25(6), 1997, pp. 1378-1384
Citations number
32
Language
INGLESE
art.tipo
Article
ISSN journal
1058-4838
Volume
25
Issue
6
Year of publication
1997
Pages
1378 - 1384
Database
ISI
SICI code
1058-4838(1997)25:6<1378:AOCDAT>2.0.ZU;2-6
Abstract
We compared antibody levels following separate but simultaneous admini stration of diphtheria and tetanus toxoids with acellular pertussis va ccine (DTaP) containing pertussis toroid, filamentous hemagglutinin, a nd pertactin (PRN); hepatitis B vaccine; and Haemophilus influenzae ty pe b polysaccharide (polyribosylribitol phosphate; PRP) vaccine conjug ated to tetanus toroid (PRP-T) with those following administration of a combination of a DTaP-hepatitis B vaccine-PRP-T to infants at 2, 4, and 6 months of age. The antibody response to a booster dose of PRP co njugate vaccine (CRM197-OS) in infants with low (<1 mu g/mL) or undete ctable (<0.10 mu g/mL) postpriming levels of antibody to PRP was also studied. Antibody levels were quantitated before and after dose 3 by e nzyme-linked immunosorbent assay, radioimmunoassay, or neutralization assay. Seroresponse rates were not different between the two vaccine g roups except for rates of response to PRP. There was a trend that leve ls of antibody to all the antigens included in the combination vaccine were lower than those of antibody to antigens in separate vaccines; f or levels of antibody to diphtheria toroid (P = .001), PRN (P < .0001) , and PRP (P < .0001), the differences were significant. Despite low o r undetectable postpriming levels of antibody to PRP, high-titered (ge ometric mean concentration, 9.02 mu g/mL; range, 1.0-81.5 mu g/mL), im munoglobulin G-predominant antibody to PRP was produced following a bo oster dose of CRM197-OS, a finding consistent with a memory response.