ANIMAL-MODELS OF RESPIRATORY SYNCYTIAL VIRUS-INFECTION

Authors
Citation
Lg. Byrd et Ga. Prince, ANIMAL-MODELS OF RESPIRATORY SYNCYTIAL VIRUS-INFECTION, Clinical infectious diseases, 25(6), 1997, pp. 1363-1368
Citations number
65
Language
INGLESE
art.tipo
Article
ISSN journal
1058-4838
Volume
25
Issue
6
Year of publication
1997
Pages
1363 - 1368
Database
ISI
SICI code
1058-4838(1997)25:6<1363:AORSV>2.0.ZU;2-A
Abstract
Over the past two decades, animal models of respiratory syncytial viru s (RSV) infection have been developed using primates, cotton rats, mic e, calves, guinea pigs, ferrets, and hamsters. Use of these models has shed light on the mechanisms of vaccine-enhanced disease seen in clin ical trials of a formalin-inactivated RSV vaccine and has provided a m eans for testing efficacy and safety of candidate prophylactic and the rapeutic strategies. The development of multiple animal models has coi ncided with the realization that RSV disease in humans is a multifacet ed disease whose clinical manifestations and sequelae depend upon age, genetic makeup, immunologic status, and concurrent disease within sub populations. There is no single human subpopulation in whom all forms of RSV disease manifest, nor is there a single animal model that dupli cates all forms of RSV disease. The choice of an experimental model wi ll be governed by the specific manifestation of disease to be studied.