COLONIC ENDOCRINE-CELLS IN INFLAMMATORY BOWEL-DISEASE

Citation
M. Elsalhy et al., COLONIC ENDOCRINE-CELLS IN INFLAMMATORY BOWEL-DISEASE, Journal of internal medicine, 242(5), 1997, pp. 413-419
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
ISSN journal
0954-6820
Volume
242
Issue
5
Year of publication
1997
Pages
413 - 419
Database
ISI
SICI code
0954-6820(1997)242:5<413:CEIIB>2.0.ZU;2-D
Abstract
Objectives. To study colonic endocrine cell types in patients with ulc erative colitis (UC) and Crohn's disease (CD). Setting. Departments of Medicine and Pathology, University Hospitals, Umea and Uppsala, Swede n. Subjects. Seventeen patients with UC (seven females and 10 males) a nd 11 patients with CD (five females and six males). Twenty-two patien ts (eight females and 14 males) operated on for colon carcinoma and wi thout signs of inflammatory bowel disease were used as controls. Measu rements. The colonic endocrine cell types were identified by immunohis tochemical methods and quantified by computed image analysis. Results. The areas of the argyrophil cells as well as these immunoreactive to chromogranin A and serotonin were significantly increased in patients with both UC and CD, compared with those in the controls. In patients with CD, the areas of polypeptide YY(PYY)- and pancreatic polypeptide (PP)-immunoreactive cells were significantly reduced, whilst the area of enteroglucagon-immunoreactive cells was increased. There was no sta tistical difference in endocrine cell area between specimens with slig ht versus severe inflammation, except for PYY and enteroglucagon cell areas in patients with CD. Whilst the former cell area decreased, the latter increased in specimens with severe inflammation. The mean cellu lar area for each endocrine cell type did not differ between the contr ols and patients with UC or CD. Conclusions. The increase in the serot onin-immunoreactive cell area in patients with both UC and CD might be one of the factors causing reduced colonic contraction and increased intraluminal pressure observed in patients with inflammatory bowel dis ease. Furthermore, in patients with CD, the decreased PYY-immunoreacti ve cell area may explain the decreased absorption and increased secret ion found in these patients.