PHASE-I STUDIES OF FLUOROURACIL, DOXORUBICIN AND VINORELBINE WITHOUT (FAN) AND WITH (SUPERFAN) FOLINIC ACID IN PATIENTS WITH ADVANCED BREAST-CANCER

Citation
Pe. Goss et al., PHASE-I STUDIES OF FLUOROURACIL, DOXORUBICIN AND VINORELBINE WITHOUT (FAN) AND WITH (SUPERFAN) FOLINIC ACID IN PATIENTS WITH ADVANCED BREAST-CANCER, Cancer chemotherapy and pharmacology, 41(1), 1997, pp. 53-60
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Oncology
ISSN journal
0344-5704
Volume
41
Issue
1
Year of publication
1997
Pages
53 - 60
Database
ISI
SICI code
0344-5704(1997)41:1<53:PSOFDA>2.0.ZU;2-7
Abstract
Purpose: The Breast Cancer Site Group of the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG) undertook two parallel pha se I studies to determine the maximum tolerated dose (MTD) and recomme nded phase II dose of vinorelbine in combination with doxorubicin and fluorouracil (with or without folinic acid) in metastatic breast cance r. Methods: Cohorts of five patients were to receive: (a) fluorouracil 500 mg/m(2) and doxorubicin 50 mg/m(2) on day 1 only and escalating d oses of vinorelbine (15, 20, 25, 30 mg/m(2)) on days 1, 8 and 15 every 3 weeks (FAN regimen), or (b) fluorouracil 340 mg/m(2) and folinic ac id 200 mg/m(2) on days 1, 2, 3, 4 and 5, doxorubicin 40 mg/m(2) on day 1 only and escalating doses of vinorelbine (15, 20, 25, 30 mg/m(2)) o n day 1 and again on day 5 every 4 weeks (SUPERFAN regimen). Eligibili ty included measurable or evaluable metastatic breast cancer and havin g received neither previous chemotherapy for metastatic disease nor an thracycline-containing adjuvant therapy. Results: Of 26 and 12 patient s enrolled in the FAN and SUPERFAN regimens, 26 and 12 were evaluable for toxicity and 21 and 9 for response, respectively. Median ages were 60.3 years (41-71 years) and 64.2 years (51-73 years). Both regimens required amendment after the first cohort with an original day-15 vino relbine dose omitted from the FAN regimen and more prolonged nadir gra nulocyte counts allowed. Myelosuppression was dose limiting. MTDs in t he FAN and SUPERFAN regimens were vinorelbine 25 mg/m(2) and 20 mg/m(2 ). Other toxicities included mucositis, septicemia and febrile neutrop enia. Peripheral neuropathy and constipation were mild. Of the 21 FAN patients evaluable for response, 3 (14%) had complete responses and 7 (33%) had partial responses, for an overall response rate of 48%; 9 (4 3%) had stable disease and 2 (9%) had progressive disease as their bes t response, Of the nine SUPERFAN patients evaluable for response, none had a complete response. There were two (22%) with partial responses, and six (67%) had stable disease and one (11%) had progressive diseas e as their best response. Conclusions: The SUPERFAN regimen was too to xic to pursue even at the lowest dose, The recommended phase II starti ng dose for the FAN regimen was vinorelbine 20 mg/m(2). Although these were phase I studies response rates in evaluable patients were less t han expected and toxicity did not allow the use of as much vinorelbine in the combinations as had been anticipated. The limited response dat a from our study would imply that combining vinorelbine with more toxi c agents may not enhance response rates and may defeat the advantage o f tolerability, especially in elderly patients.