HISTONE PHOSPHORYLATION DURING SEA-URCHIN DEVELOPMENT

Citation
Gr. Green et al., HISTONE PHOSPHORYLATION DURING SEA-URCHIN DEVELOPMENT, Seminars in cell biology, 6(4), 1995, pp. 219-227
Citations number
43
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell Biology
Journal title
ISSN journal
1043-4682
Volume
6
Issue
4
Year of publication
1995
Pages
219 - 227
Database
ISI
SICI code
1043-4682(1995)6:4<219:HPDSD>2.0.ZU;2-#
Abstract
Studies on histone phosphorylation during transitions in chromatin str ucture occurring in vivo during spermatogenesis and early embryogenesi s in sea urchins are reviewed and evaluated in the light of recent stu dies on histone phosphorylation occurring during chromatin synthesis i n frog egg extracts in vitro and evidence that protein kinases and pho sphatases play direct roles in the regulation of cellular structure. S perm-specific histone variants Sp H1 and Sp H2B are maintained as phos phorylated derivatives N and O/P throughout spermatogenesis and early embryogenesis and egg specific histone variants CS H1 and CS H2A are p hosphorylated during early embryogenesis. These developmental correlat ions provide clues about the roles of histone phosphorylation in contr ol of chromatin structure in vivo and provide a basis for the interpre tation of data obtained from in-vitro sperm chromatin remodeling in eg g extracts and from biochemical studies on the effects of histone phos phorylation on DNA binding. The potential consequences for chromatin s tructure of the various histone phosphorylation events observed in sea urchins and frog egg extracts are discussed.