JTB: A novel membrane protein gene at 1q21 rearranged in a jumping translocation

Citation
S. Hatakeyama et al., JTB: A novel membrane protein gene at 1q21 rearranged in a jumping translocation, ONCOGENE, 18(12), 1999, pp. 2085-2090
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ONCOGENE
ISSN journal
0950-9232 → ACNP
Volume
18
Issue
12
Year of publication
1999
Pages
2085 - 2090
Database
ISI
SICI code
0950-9232(19990325)18:12<2085:JANMPG>2.0.ZU;2-7
Abstract
1q21 is frequently involved in different types of translocation in many typ es of cancers. Jumping translocation (JT) is an unbalanced translocation th at comprises amplified chromosomal segments jumping to various telomeres. I n this study, we identified a novel gene human JTB (Jumping Translocation B reakpoint) at 1q21, which fused with the telomeric repeats of acceptor telo meres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein th at is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the t rans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex). This is the first report identify ing the gene involved in unbalanced translocations at 1q21.