The naturally occurring taxoid baccatin VI has been converted to various 1-
deoxypaclitaxel derivatives by selective deacylation followed by attachment
of the C-13 side chain. The bioactivities of the resulting analogues were
determined in both tubulin polymerization and cytotoxicity assays, and seve
ral analogues with activity comparable to that of paclitaxel were discovere
d. It thus appears that the l-hydroxyl group is not necessary for the activ
ity of paclitaxel.