Dietary vitamin A and teratogenic risk: European Teratology Society discussion paper

Citation
Hm. Dolk et al., Dietary vitamin A and teratogenic risk: European Teratology Society discussion paper, EUR J OB GY, 83(1), 1999, pp. 31-36
Citations number
52
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN journal
0301-2115 → ACNP
Volume
83
Issue
1
Year of publication
1999
Pages
31 - 36
Database
ISI
SICI code
0301-2115(199903)83:1<31:DVAATR>2.0.ZU;2-Y
Abstract
This review discusses the predictive value of animal models in assessment o f possible risk from excess vitamin A consumption during pregnancy and the human evidence concerning risk of congenital malformations from excess vita min A in the diet, consumed either as a constituent of normal foods or in t he form of dietary vitamin supplements. Other sources of exposure to vitami n A include medicines (dermal and oral preparations) and cosmetics, but the se are not further considered here. Conservative estimates of the likely sa fe intake of vitamin A during pregnancy are available, based on results fro m scientific research to date. However, current uncertainties are such that further research is needed to more clearly define intakes which may be on the borderline between those which are beneficial and those which may pose a risk to the developing embryo and fetus. (C) 1999 Elsevier Science Irelan d Ltd All rights reserved.