Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and re
lated compounds were synthesized and evaluated for their in vitro cytotoxic
ity against a panel of human tumor cell lines. The most active compound (3)
showed significant cytotoxic activity with GI(50) values in the micromolar
range. (C) 1999 Elsevier Science Ltd. All rights reserved.