Denervation of the skin following section of the inferior alveolar nerve leads to increased NGF accumulation without change in NGF mRNA expression

Citation
Sj. Harper et al., Denervation of the skin following section of the inferior alveolar nerve leads to increased NGF accumulation without change in NGF mRNA expression, EXP NEUROL, 155(2), 1999, pp. 327-330
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
EXPERIMENTAL NEUROLOGY
ISSN journal
0014-4886 → ACNP
Volume
155
Issue
2
Year of publication
1999
Pages
327 - 330
Database
ISI
SICI code
0014-4886(199902)155:2<327:DOTSFS>2.0.ZU;2-R
Abstract
Following inferior alveolar nerve section and capping of the nerve to preve nt regeneration, amounts of nerve growth factor (NGF) and NGF mRNA have bee n quantified in the chin skin, a discrete target of the nerve. NGF protein in the target region increases rapidly following nerve section and to level s known to induce sprouting. NGF on the ipsilateral side increased many-fol d above unoperated control and the contralateral side also increased above control. Measurement of NGF mRNA levels using quantitative Northern analysi s revealed, however, that there was no change in the expression levels of N GF mRNA, indicating that the large increase in protein occurs due to a cess ation of transport back to the cell bodies of the innervating neurons. (C) 1999 Academic Press.