Portal blood flow and liver regeneration in auxiliary partial orthotopic liver transplantation in a canine model

Citation
S. Yabe et al., Portal blood flow and liver regeneration in auxiliary partial orthotopic liver transplantation in a canine model, EUR SURG RE, 31(1), 1999, pp. 83-92
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
EUROPEAN SURGICAL RESEARCH
ISSN journal
0014-312X → ACNP
Volume
31
Issue
1
Year of publication
1999
Pages
83 - 92
Database
ISI
SICI code
0014-312X(199901/02)31:1<83:PBFALR>2.0.ZU;2-P
Abstract
Functional competition has been shown to lead to a detrimental outcome in a uxiliary liver transplantation. We evaluated the interaction in auxiliary p artial orthotopic liver transplantation between the native liver and the gr aft in terms of portal flow and regeneration. The need for diversion of the portal Row to the graft was also assessed, Reduced-size liver grafts were transplanted orthotopically after partial hepatectomy in beagles. There wer e two groups: the preserved group, where portal inflow to the native liver was preserved, and the ligated group, where it was interrupted. Portal flow was measured serially and liver regeneration was evaluated on postoperativ e day 5. Functional competition was not observed in the preserved group. On the other hand, ligation of the native liver portal vein had no obviously detrimental effects on the remnant native liver. This leads to the conclusi on that the portal vein to the native liver can be safely ligated to preven t functional competition.