Portal blood flow and liver regeneration in auxiliary partial orthotopic liver transplantation in a canine model

Yabe, S Nishizawa, H Egawa, H Nakayama, H Okamoto, S Kiuchi, T Uemoto, S Asonuma, K Shapiro, AMJ Inomata, Y Yamaoka, Y Tanaka, K

S. Yabe et al., Portal blood flow and liver regeneration in auxiliary partial orthotopic liver transplantation in a canine model, EUR SURG RE, 31(1), 1999, pp. 83-92

38

INGLESE

Article

Surgery,"Medical Research Diagnosis & Treatment

EUROPEAN SURGICAL RESEARCH

0014-312X → ACNP

31

1

1999

83 - 92

ISI

0014-312X(199901/02)31:1<83:PBFALR>2.0.ZU;2-P

Functional competition has been shown to lead to a detrimental outcome in a uxiliary liver transplantation. We evaluated the interaction in auxiliary p artial orthotopic liver transplantation between the native liver and the gr aft in terms of portal flow and regeneration. The need for diversion of the portal Row to the graft was also assessed, Reduced-size liver grafts were transplanted orthotopically after partial hepatectomy in beagles. There wer e two groups: the preserved group, where portal inflow to the native liver was preserved, and the ligated group, where it was interrupted. Portal flow was measured serially and liver regeneration was evaluated on postoperativ e day 5. Functional competition was not observed in the preserved group. On the other hand, ligation of the native liver portal vein had no obviously detrimental effects on the remnant native liver. This leads to the conclusi on that the portal vein to the native liver can be safely ligated to preven t functional competition.