Ventilatory response and arterial blood gases during exercise in children

Citation
H. Ohuchi et al., Ventilatory response and arterial blood gases during exercise in children, PEDIAT RES, 45(3), 1999, pp. 389-396
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
PEDIATRIC RESEARCH
ISSN journal
0031-3998 → ACNP
Volume
45
Issue
3
Year of publication
1999
Pages
389 - 396
Database
ISI
SICI code
0031-3998(199903)45:3<389:VRAABG>2.0.ZU;2-#
Abstract
To investigate the difference in ventilatory response to exercise between c hildren and young adults, we administered a treadmill progressive exercise test to seven boys (aged 8 to 11 y [group A]) and six male young adults (ag ed 14 to 21 y [group B]), who had a history of Kawasaki disease without sig nificant coronary arterial lesions, and analyzed their arterial blood gases . There was no significant difference in arterial Po-2 or the end-tidal to arterial oxygen tension difference during exercise between groups A and B. The arterial Pco(2) (Paco(2)) at the ventilatory anaerobic threshold and at peak exercise was significantly lower in group A than in group B (p < 0.05 ). The arterial to end-tidal carbon dioxide tension difference at peak exer cise was significantly greater in group B than in group A (p < 0.05), where as there was no significant difference at rest or at the ventilatory anaero bic threshold level. The arterial to end-tidal carbon dioxide tension diffe rence at peak exercise was correlated with tidal volume p < 0.01) and carbo n dioxide production (p < 0.05) at peak exercise in all subjects. Although improvement in the physiologic dead space/tidal volume ratio during exercis e was smaller in group A than in group B, there was no significant differen ce in total alveolar ventilation during exercise. However, the total carbon dioxide production during exercise was significantly smaller in group A th an in group B. These data suggest that Paco(2) during exercise is better es timated by end-tidal carbon dioxide tension in children than in young adult s, that there is a significant difference in change of the Paco(2) during e xercise between children and young adults, and that the decrease in Paco(2) in children is related to the mismatch between well-maintained alveolar ve ntilation and immature metabolic development in the working muscles during moderate-to-severe exercise.