Outcome of tuberculous meningitis at 6 and 12 months: a multiple regression analysis

Citation
J. Kalita et Uk. Misra, Outcome of tuberculous meningitis at 6 and 12 months: a multiple regression analysis, INT J TUBE, 3(3), 1999, pp. 261-265
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
ISSN journal
1027-3719 → ACNP
Volume
3
Issue
3
Year of publication
1999
Pages
261 - 265
Database
ISI
SICI code
1027-3719(199903)3:3<261:OOTMA6>2.0.ZU;2-Z
Abstract
OBJECTIVE: There are few studies on the long-term outcome of tuberculous me ningitis (TBM) employing multivariate analysis. The present study was under taken to evaluate the outcome predictors of TBM at 6 and 12 months. METHOD: Those patients with TBM who could be sequentially followed up for 6 and 12 months were included in this prospective, hospital-based study. The outcome was defined at 6 and 12 months by Barthel Index (BI) score into co mplete (BI = 20), partial (BI 12-19) and poor (BI < 12). Death was included in the 'poor recovery' group for statistical analysis. A number of clinica l, laboratory and radiological parameters were evaluated by multiple regres sion analysis. RESULTS: Fifty-eight patients with TBM aged between 1 and 64 years (mean 25 .6 years), 18 of whom were females and 17 children below 12 years, were inc luded in the study. Fifty-eight patients were followed up for 6 months and 56 for 12 months. At 6 months' follow-up 37 patients had complete recovery, three partial, six poor and 12 had died. At 12 months, 40 patients had com plete recovery, one partial and three poor. The best set of parameters pred icting outcome at 6 and 12 months included stage of TBM, Glasgow coma scale (GCS) and brain infarction. CONCLUSION: This study highlights the importance of stage of meningitis, GC S and infarction in predicting the long term outcome of tuberculous meningi tis.