Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome

Citation
Ljm. Reichert et al., Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome, NEPH DIAL T, 14(1), 1999, pp. 91-97
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
NEPHROLOGY DIALYSIS TRANSPLANTATION
ISSN journal
0931-0509 → ACNP
Volume
14
Issue
1
Year of publication
1999
Pages
91 - 97
Database
ISI
SICI code
0931-0509(199901)14:1<91:AHAPEO>2.0.ZU;2-A
Abstract
Background. Administration of prednisolone causes an abrupt rise in protein uria in patients with a nephrotic syndrome. Methods. To clarify the mechanisms responsible for this increase in protein uria we have performed a placebo controlled study in 26 patients with a nep hrotic syndrome. Systemic and renal haemodynamics and urinary protein excre tion were measured after prednisolone and after placebo. Results. After i.v. administration of 125-150mg prednisolone total proteinu ria increased from 6.66 +/- 4.42 to 9.37 +/- 6.07 mg/min (P < 0.001). By an alysing the excretion of proteins with different charge and weight (albumin , transferrin, IgG, IgG(4) and beta(2)-microglobulin) it became apparent th at the increase of proteinuria was the result of a change in size selectivi ty rather than a change in glomerular charge selectivity or tubular protein reabsorption. Glomerular filtration rate rose from 83 +/- 34 ml to 95 +/- 43 ml/min (P < 0.001) after 5 h, whereas effective renal plasma flow and en dogenous creatinine clearance remained unchanged. As a result filtration fr action was increased, compatible with an increased glomerular pressure, whi ch probably contributes to the size selectivity changes. Since cortico-ster oids affect both the renin-angiotensin system and renal prostaglandins, we have evaluated the effects of prednisolone on proteinuria after pretreatmen t with 3 months of the angiotensin-converting enzyme inhibitor lisinopril o r after 2 weeks of the prostaglandin synthesis inhibitor indomethacin. Neit her drug had any effect on prednisolone-induced increases of proteinuria. Conclusions. Prednisolone increases proteinuria by changing the size select ive barrier of the glomerular capillary. Neither the renin-angiotensin axis nor prostaglandins seem to be involved in these effects of prednisolone on proteinuria.