SOLUBLE E-SELECTIN AND VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN PRIMARY BILIARY-CIRRHOSIS

Citation
Ag. Lim et al., SOLUBLE E-SELECTIN AND VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN PRIMARY BILIARY-CIRRHOSIS, Journal of hepatology, 22(4), 1995, pp. 416-422
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
0168-8278
Volume
22
Issue
4
Year of publication
1995
Pages
416 - 422
Database
ISI
SICI code
0168-8278(1995)22:4<416:SEAVCM>2.0.ZU;2-J
Abstract
Background/Aims: E-selectin and vascular cell adhesion molecule-1, imp ortant in leucocyte adhesion, have recently been detected in soluble f orm in the circulation. However, their clinical significance remains n uclear. Our aims were to determine whether the levels of these molecul e are increased in primary biliary cirrhosis, and to relate these to h istological disease stage, biochemical measures of liver damage and to lymphocyte activation. Methods: We studied 42 patients with primary b iliary cirrhosis, nine with primary sclerosing cholangitis, 14 with al coholic liver disease and 17 healthy subjects. Circulating E-selectin and vascular cell adhesion molecule-1 levels were measured by enzyme-l inked immunosorbent assay. In subgroups of patients with primary bilia ry cirrhosis, hepatic bile acid uptake and excretory rates and T-cell activation were also determined. Results: Soluble E-selectin and vascu lar cell adhesion molecule-1 levels were significantly elevated in pri mary biliary cirrhosis compared to healthy controls. However, there wa s no difference between primary biliary cirrhosis and other liver dise ase groups. In primary biliary cirrhosis, both adhesion molecules corr elated with disease stage, but differed in their relationships with sp ecific liver function tests. They did not correlate with either hepati c bile acid uptake or excretion, or lymphocyte activation. Conclusions : We conclude that soluble E-selectin and vascular cell adhesion molec ule-1 are elevated in chronic liver diseases. In primary biliary cirrh osis, they reflect the stage of disease and may reflect the degree of leucocyte adhesion and migration.