Current clinical trials for the treatment of adult Hodgkin's disease: Common strategies and perspectives

Citation
J. Wolf et al., Current clinical trials for the treatment of adult Hodgkin's disease: Common strategies and perspectives, ANN ONCOL, 9, 1998, pp. 79-82
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
ANNALS OF ONCOLOGY
ISSN journal
0923-7534 → ACNP
Volume
9
Year of publication
1998
Supplement
5
Pages
79 - 82
Database
ISI
SICI code
0923-7534(1998)9:<79:CCTFTT>2.0.ZU;2-J
Abstract
Strategies in the treatment of adult Hodgkin's disease (HD) are changing st rikingly in current clinical trials. In early as well as in intermediate st age HD a common aim of most study groups now is the reduction of radiation dose and volume in order to minimize severe late effects like myocardial da mage and secondary neoplasias. As a consequence extended field irradiation is abandoned in nearly all trials, and combined modality treatment will be used not only in intermediate. but also in early stage HD. In advanced stag e HD new chemotherapy regimens, based on the principle of a moderate dose e scalation, for the first time seem to improve the therapeutic outcome. Thus , the priority in current clinical trials for advanced stage HD is the long -term evaluation of these new regimens with regard to treatment efficacy an d toxicity.