Surgical treatment of epilepsy - clinical, radiological and histopathological findings in 139 children and adults

Citation
S. Eriksson et al., Surgical treatment of epilepsy - clinical, radiological and histopathological findings in 139 children and adults, ACT NEUR SC, 99(1), 1999, pp. 8-15
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ACTA NEUROLOGICA SCANDINAVICA
ISSN journal
0001-6314 → ACNP
Volume
99
Issue
1
Year of publication
1999
Pages
8 - 15
Database
ISI
SICI code
0001-6314(199901)99:1<8:STOE-C>2.0.ZU;2-2
Abstract
The present study relates clinical and radiological data to histopathologic al diagnoses in the first 139 patients (children and adults) in the Gotebor g Epilepsy Surgery series. Temporal lobe resections were most common (54.0% ) followed by frontal lobe (18.0%) and multilobar resections (11.5%). All h istopathological specimens were re-evaluated in connection with this study. Parenchymal malformations and atrophic-gliotic lesions were the most commo n histopathological findings. Microdysgenesis was more common than major ma lformations (24.5% versus 11.5%). When the MRI scans were blindly re-evalua ted the MRI findings correlated with histopathological diagnosis in all of the vascular malformations, in 77.8% of the tumours, in 76.5% of the cases with hippocampal sclerosis but only in 28.6% of the major cortical developm ent malformations. Hemispherectomies carried the best seizure outcome prognosis followed by te mporal lobe resections (75.0% versus 57.3% seizure free 2 years after surge ry). Vascular malformations carried the best, and microdysgenesis the worst prognosis (76.9% versus 39.4% seizure free).