Increased truncated form of plasma tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation

Citation
M. Shimura et al., Increased truncated form of plasma tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation, AM J HEMAT, 60(2), 1999, pp. 94-98
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
0361-8609 → ACNP
Volume
60
Issue
2
Year of publication
1999
Pages
94 - 98
Database
ISI
SICI code
0361-8609(199902)60:2<94:ITFOPT>2.0.ZU;2-Z
Abstract
To evaluate that the relationship between the truncated form of tissue fact or pathway inhibitor (TFPI) and the stage of disseminated intravascular coa gulation (DIC), we measured the plasma levels of tissue factor (TF) antigen and the intact and truncated forms of TFPI antigens in 41 patients with DI G, 12 with pre-DIG, and 20 with non-DIG. The plasma TF and total TFPI antig en levels were significantly higher in patients with DIG than in non-DIG pa tients. Plasma levels of intact TFPI antigen in the pre-DIG groups were sig nificantly lower than in the non-DIG and DIG groups. The truncated form of TFPI antigen levels in DIG patients were significantly increased compared w ith those in non-DIG and pre-DIG patients. The fact that the intact form of TFPI was decreased in pre-DIG patients compared with that in non-DIG patie nts, suggests that it is consumed in the pre-DIG state and that hypercoagul ability occurs in pre-DIG patients. The increased level of the truncated fo rm of TFPI in DIG patients may be attributed to proteolysis of the intact f orm of TFPI in these patients. The increased level of the truncated form of TFPI may be a useful index for the diagnosis of DIG. (C) 1999 Wiley-Liss, Inc.