Successive follow-up of chest computed tomography in patients with Mycobacterium avium-intracellulare complex

Citation
Y. Obayashi et al., Successive follow-up of chest computed tomography in patients with Mycobacterium avium-intracellulare complex, RESP MED, 93(1), 1999, pp. 11-15
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
RESPIRATORY MEDICINE
ISSN journal
0954-6111 → ACNP
Volume
93
Issue
1
Year of publication
1999
Pages
11 - 15
Database
ISI
SICI code
0954-6111(199901)93:1<11:SFOCCT>2.0.ZU;2-C
Abstract
The aim of this study was to evaluate the changes in chest CT findings exam ined successively in patients with Mycobacterium avium intracellulare compl ex (MAC) infection. We carried out a retrospective study of 25 patients wit h MAC infection who had serial CT scans. Patients included 18 women and sev en men with a median age of 66 years. Mean (+/- SE) follow-up interval betw een the first and second CT was 27.5 +/- 4.2 months. The serial chest CT scans were reviewed with consensus reading by two obser vers. At the first chest CT examination, we found the following: bronchiect asis in (133 of 250 fields), cavity formation (11 of 250 fields), centrilob ular nodules (167 of 250 fields), air-space disease (30 of 250 fields) and nodules (81 of 250 fields). The middle lobe and lingula were frequently inv olved. Centrilobular nodule scores improved in seven patients; disease prog ressed in nine patients and was stable in nine patients. In addition, bronc hiectasis scores improved in four patients; disease progressed in 15 patien ts and was stable in six patients. The score of bronchiectasis in the secon d CT was significantly higher than in the first CT. In conclusion, our data suggest that centrilobular nodules and bronchiectasis are frequent observa tions in patients with: MAC. In addition, progression of bronchiectasis app eared to be caused by MAC infection.