Clusters of Pneumocystis carinii pneumonia: analysis of person-to-person transmission by genotyping

Citation
J. Helweg-larsen et al., Clusters of Pneumocystis carinii pneumonia: analysis of person-to-person transmission by genotyping, QJM-MON J A, 91(12), 1998, pp. 813-820
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
ISSN journal
1460-2725 → ACNP
Volume
91
Issue
12
Year of publication
1998
Pages
813 - 820
Database
ISI
SICI code
1460-2725(199812)91:12<813:COPCPA>2.0.ZU;2-Z
Abstract
Genotyping at the internal transcribed spacer (ITS) regions of the nuclear rRNA operon was performed on isolates of P. carinii sp. f. hominis from thr ee clusters of P. carinii pneumonia among eight patients with haematologica l malignancies and six with HIV infection. Nine different ITS sequence type s of P. carinii sp. f. hominis were identified in the samples from the pati ents with haematological malignancies, suggesting that this cluster of case s of P. carinii pneumonia was unlikely to have resulted from nosocomial tra nsmission. A common ITS sequence type was observed in two of the patients w ith haematological malignancies who shared a hospital room, and also in two of the patients with HIV infection who had prolonged close contact on the ward. In contrast, different ITS sequence types were detected in samples fr om an HIV-infected homosexual couple who shared the same household. These d ata suggest that person-to-person transmission of P. carinii sp. f. hominis may occur from infected to susceptible immunosuppressed patients with clos e contact within hospital environments. However direct transmission between patients did not account for the majority of cases within the clusters, su ggesting that person-to-person transmission of P. carinii sp. f. hominis in fection may be a relatively infrequent event and does not constitute the ma jor route of transmission in man.