Acquired immunity and postnatal clinical protection in childhood cerebral malaria

Citation
S. Gupta et al., Acquired immunity and postnatal clinical protection in childhood cerebral malaria, P ROY SOC B, 266(1414), 1999, pp. 33-38
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
ISSN journal
0962-8452 → ACNP
Volume
266
Issue
1414
Year of publication
1999
Pages
33 - 38
Database
ISI
SICI code
0962-8452(19990107)266:1414<33:AIAPCP>2.0.ZU;2-J
Abstract
By analysing data on the age distribution of cerebral malaria among sites o f different transmission intensities, we conclude that the most plausible e xplanation for the epidemiological patterns seen is that (i) cerebral malar ia is caused by a distinct set of Plasmodium falciparum antigenic types; (i i) these antigenic types or 'CM strains' are very common and induce strong strain-specific immunity; and (iii) the postnatal period of protection agai nst cerebral malaria is much longer than the period of protection against o ther forms of severe disease. The alternative hypothesis that cerebral mala ria may be caused by any 'strain' of P. falciparum is compatible with the d ata only if a single exposure is sufficient to protect against further epis odes. This is not consistent with observations on the history of exposure o f patients with cerebral malaria. Finally, it is clear that although the de layed peak in incidence of cerebral malaria (with age) can be generated by assuming that subsequent exposures carry a higher risk of disease, such an explanation is not compatible with the observation that severe disease rate s are low among infants and young children in areas of high transmissibilit y.