Serial electroencephalographic findings in patients with MELAS

Citation
S. Fujimoto et al., Serial electroencephalographic findings in patients with MELAS, PED NEUROL, 20(1), 1999, pp. 43-48
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
PEDIATRIC NEUROLOGY
ISSN journal
0887-8994 → ACNP
Volume
20
Issue
1
Year of publication
1999
Pages
43 - 48
Database
ISI
SICI code
0887-8994(199901)20:1<43:SEFIPW>2.0.ZU;2-9
Abstract
To clarify the electroencephalographic characteristics of mitochondrial myo pathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS), th e medical records and electroencephalograms of six patients with MELAS and two of their relatives with MELA (mitochondrial myopathy, encephalopathy, a nd lactic acidosis, without strokelike episodes) were retrospectively revie wed. All have a point mutation in the mitochondrial DNA at nucleotide posit ion 3243, The electroencephalograms (n = 79) were divided into four groups according to the time relation to the strokelike episode: (1) before the fi rst strokelike episode, (2) within 5 days after the strokelike episode (acu te stage), (3) between 6 days and 1 month after the strokelike episode (sub acute stage), and (4) more than 1 month after the strokelike episode (chron ic stage). In the acute stage, 10 of the 11 electroencephalograms (9 stroke like episodes in four patients) revealed focal high-voltage delta waves wit h polyspikes (FHDPS), which were recognized as ictal electroencephalogram. Ictal events during FHDPS included focal clonic or myoclonic seizure and mi grainous headache. In the subacute and chronic stages, focal spikes or shar p waves and 14- and 6-Hz positive bursts were frequently recorded, The auth ors' results suggest that FHDPSs present a reliable and accurate indicator of a strokelike episode in patients with MELAS. (C) 1999 by Elsevier Scienc e Inc. All rights reserved.