Citation

Cj. Fitzsimons et al., A novel algorithm for tracing the interaction of a track with molecular targets - use of Delaunay triangulation, MATH BIOSCI, 154(2), 1998, pp. 103-115

Citations number

23

Language

INGLESE

art.tipo

Article

Categorie Soggetti

Multidisciplinary

Journal title

MATHEMATICAL BIOSCIENCES

ISSN journal

0025-5564
→ ACNP

Volume

154

Issue

2

Year of publication

1998

Pages

103 - 115

Database

ISI

SICI code

0025-5564(199812)154:2<103:ANAFTT>2.0.ZU;2-N

Abstract

This paper describes an efficient method for tracing interactions between a
radiation track and molecular targets in a cell or nucleus. The method is
efficient because it ensures that a minimal subset of interactions in the t
rack needs to be tested for each score. It is most useful for high-energy p
articles since the number of interactions and range of the tracks increase
with particle energy. In this method, the set of interactions, i.e. the tra
ck, is considered as a collection of points in three-dimensional space. Thi
s set, together with the eight vertices of a bounding box, is discretised a
s a collection of tetrahedra, each of which satisfies the Delaunay criterio
n. Because of the geometric properties of these tetrahedra, only those poin
ts which are connected to vertices of tetrahedra through which the target p
asses need be tested for scoring. An efficient algorithm is used to follow
the track through the cell or the nucleus. The main benefit of the method i
s that it eliminates the need to test those interactions which are geometri
cally distant from the target. In particular, in cases where there are no i
nteractions in the target, very few interactions need to be checked. (C) 19
98 Elsevier Science Inc. All rights reserved.