Imbalanced expression of functionally different WT1 isoforms may contribute to sporadic unilateral Wilms' tumor

Citation
Jj. Liu et al., Imbalanced expression of functionally different WT1 isoforms may contribute to sporadic unilateral Wilms' tumor, BIOC BIOP R, 254(1), 1999, pp. 197-199
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006-291X → ACNP
Volume
254
Issue
1
Year of publication
1999
Pages
197 - 199
Database
ISI
SICI code
0006-291X(19990108)254:1<197:IEOFDW>2.0.ZU;2-O
Abstract
Functional loss of the product of the Wilm's tumor suppressor gene (wt1) ha s been identified in subsets of familial Wilms' tumors. Previously, four al ternative splice products of WT1 were recognized and each was found to regu late transcription of effector genes differently, suggesting that disruptio n of the normal ratio of these spliced products will disrupt the normal exp ression patterns of WT1 effector genes and perhaps lead to Wilms' tumor. In support of these suggestions, we found that four of seven cases of sporadi c unilateral Wilms' tumor had striking differences in the ratios of the spl iced products of WT1 compared with each other and normal kidney. These data indicate that in addition to structural mutations, alterations in the rela tive amounts of the mature WT1 isoforms may also be important in the etiolo gy of sporadic Wilms' tumor. (C) 1999 Academic Press.