Non-Hodgkin's lymphoma associated with Gaucher's disease

Citation
M. Perales et al., Non-Hodgkin's lymphoma associated with Gaucher's disease, LEUK LYMPH, 31(5-6), 1998, pp. 609-612
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
31
Issue
5-6
Year of publication
1998
Pages
609 - 612
Database
ISI
SICI code
1042-8194(199811)31:5-6<609:NLAWGD>2.0.ZU;2-N
Abstract
Gaucher's disease is an uncommon disorder which has been reported to be ass ociated with an increased risk of lymphoproliferative disorders, including Non-Hodgkin's lymphoma (NHL). A new instance of such an association is desc ribed here. This was a 58 year-old-patient with adult type I Gaucher's dise ase who, one and a half year after the above diagnosis, presented with supr aclavicular lymphadenopathy, massive splenomegaly, prominent retroperitonea l lymphadenopathy and increased serum LDH levels. This led to the diagnosis of large-cell NHL of B-cell type, successfully treated with chemotherapy. The previously published cases of Gaucher's disease associated with NHL as well as the possible mechanisms leading to this association are reviewed he re.