No relationship between gastric pH, small bowel bacterial colonisation, and diarrhoea in HIV-1 infected patients

Citation
Cm. Wilcox et al., No relationship between gastric pH, small bowel bacterial colonisation, and diarrhoea in HIV-1 infected patients, GUT, 44(1), 1999, pp. 101-105
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
GUT
ISSN journal
0017-5749 → ACNP
Volume
44
Issue
1
Year of publication
1999
Pages
101 - 105
Database
ISI
SICI code
0017-5749(199901)44:1<101:NRBGPS>2.0.ZU;2-C
Abstract
Background/Aims-Conclusive studies of small bowel bacterial overgrowth in p atients with HIV-1 infection are limited. The relation was therefore determ ined between the quantity and species of bacteria in the proximal small int estine of HIV-1 infected patients and the presence of diarrhoea, gastric ac idity, severity of immune deficiency, and clinical outcome. Methods-Bacteria in the duodenal fluids obtained endoscopically from 32 HIV -1 infected patients, 21 of whom had diarrhoea, and seven control subjects without HIV-1 risk factors were quantified and speciated. Gastric pH was de termined at the time of endoscopy. Clinical follow up was performed to asse ss outcome. Results-Oropharyngeal Gram positive cocci were present in fluids from 28 pa tients (88%). Gram negative aerobic or facultatively anaerobic bacteria wer e present in fluids from 12 patients (38%), and strict anaerobes were detec ted in six patients (19%), but for both groups colony counts infrequently e xceeded 10(4) colony forming units/ml. The number and species of bacteria d id not correlate with the presence of diarrhoea, gastric pH, or CD4 lymphoc yte count. Conclusions-Small bowel bacterial overgrowth is not common in HIV-1 infecte d patients, regardless of the presence of diarrhoea, and is not associated with hypochlorhydria.