Administration of progesterone before oocyte retrieval negatively affects the implantation rate

Citation
Sh. Sohn et al., Administration of progesterone before oocyte retrieval negatively affects the implantation rate, FERT STERIL, 71(1), 1999, pp. 11-14
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
FERTILITY AND STERILITY
ISSN journal
0015-0282 → ACNP
Volume
71
Issue
1
Year of publication
1999
Pages
11 - 14
Database
ISI
SICI code
0015-0282(199901)71:1<11:AOPBOR>2.0.ZU;2-K
Abstract
Objective: To compare the efficacy of two clinically accepted methods of pr ogesterone supplementation during IVF. Design: Prospective randomized trial. Setting: A university-based IVF program. Patient(s): Three hundred fourteen stimulated IVF cycles between January 19 93 and October 1994. Intervention(s): Patients were assigned to one of two luteal phase progeste rone regimens by a random permuted block design. In protocol A, 12.5 mg of IM progesterone was given 12 hours before oocyte retrieval; in protocol B, 25 mg of IM progesterone was given on the day of oocyte retrieval. Main Outcome Measure(s): Clinical pregnancy. Result(s): Patient demographic characteristics, including age, diagnosis, n umber of oocytes retrieved and fertilized, and number of embryos transferre d, were not different between the two groups. There was no difference in th e rate of cycle cancellation between the groups. One hundred forty ETs were performed in patients assigned to protocol A and 142 in patients assigned to protocol B. The clinical pregnancy rate in group A was 12.9% compared wi th 24.6% in group B. Conclusion(s): The administration of progesterone before oocyte retrieval i s associated with a lower pregnancy rate than the administration of progest erone after oocyte retrieval. (C) 1998 by American Society for Reproductive Medicine.