Objective: To compare the efficacy of two clinically accepted methods of pr
ogesterone supplementation during IVF.
Design: Prospective randomized trial.
Setting: A university-based IVF program.
Patient(s): Three hundred fourteen stimulated IVF cycles between January 19
93 and October 1994.
Intervention(s): Patients were assigned to one of two luteal phase progeste
rone regimens by a random permuted block design. In protocol A, 12.5 mg of
IM progesterone was given 12 hours before oocyte retrieval; in protocol B,
25 mg of IM progesterone was given on the day of oocyte retrieval.
Main Outcome Measure(s): Clinical pregnancy.
Result(s): Patient demographic characteristics, including age, diagnosis, n
umber of oocytes retrieved and fertilized, and number of embryos transferre
d, were not different between the two groups. There was no difference in th
e rate of cycle cancellation between the groups. One hundred forty ETs were
performed in patients assigned to protocol A and 142 in patients assigned
to protocol B. The clinical pregnancy rate in group A was 12.9% compared wi
th 24.6% in group B.
Conclusion(s): The administration of progesterone before oocyte retrieval i
s associated with a lower pregnancy rate than the administration of progest
erone after oocyte retrieval. (C) 1998 by American Society for Reproductive