The identification of monoclonality in human aberrant crypt foci

Citation
Im. Siu et al., The identification of monoclonality in human aberrant crypt foci, CANCER RES, 59(1), 1999, pp. 63-66
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER RESEARCH
ISSN journal
0008-5472 → ACNP
Volume
59
Issue
1
Year of publication
1999
Pages
63 - 66
Database
ISI
SICI code
0008-5472(19990101)59:1<63:TIOMIH>2.0.ZU;2-A
Abstract
Malignant neoplasms, including colon cancers, are thought to arise from a s ingle initiated progenitor cell. Aberrant crypt foci (ACF) are putative pre cursors of at least some colon cancers. The pattern of X chromosomal inacti vation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determi ne the clonality status of 11 ACP from eight female patients. Ten of II ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclo nal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a hi gh percentage of ACF lesions are neoplastic rather than hyperplastic; and ( b) ACF are the earliest identified neoplastic lesions in the colon.