Resection with external beam and intraoperative radiotherapy for recurrentcolon cancer

Citation
Rd. Pezner et al., Resection with external beam and intraoperative radiotherapy for recurrentcolon cancer, ARCH SURG, 134(1), 1999, pp. 63-67
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
ARCHIVES OF SURGERY
ISSN journal
0004-0010 → ACNP
Volume
134
Issue
1
Year of publication
1999
Pages
63 - 67
Database
ISI
SICI code
0004-0010(199901)134:1<63:RWEBAI>2.0.ZU;2-#
Abstract
Objective: To review treatment outcomes for patients with locoregional recu rrent colon cancer who underwent resection, intraoperative radiotherapy (IO RT), and external beam radiotherapy (EBRT). Design: Retrospective study of patients treated between January 1990 and Ju ne 1994. Setting: Tertiary care cancer center. Patients: Eleven patients with bulky recurrent colon cancer extending to ad jacent organs or structures signed informed consent forms to receive IORT. Intervention: Of 10 patients who underwent exploratory laparotomy, 5 had no metastatic disease and underwent resection, IORT, and EBRT. Complete resec tion was accomplished in 4 patients. Doses of IORT ranged from 13 to 20 Gy depending on residual tumor burden; EBRT was typically delivered postoperat ively to a dose of 45 Gy. Main Outcome Measures: Survival and locoregional tumor control. Results: All 4 patients who underwent complete resection, IORT, and EBRT ar e alive without locoregional recurrence 53 to 77 months after treatment. Of these, only I patient developed distant metastases. The fifth patient, who had gross residual tumor, developed local recurrence 5 months after IORT. One patient developed an IORT complication-ureteral fibrosis leading to ips ilateral nephrectomy. Conclusion: Long-term disease-free survival can be achieved in selected pat ients with bulky regional recurrence of colon cancer with complete tumor re section, IORT, and EBRT.