Structure-activity relationships of protoberberines having antimicrobial activity

Citation
K. Iwasa et al., Structure-activity relationships of protoberberines having antimicrobial activity, PLANTA MED, 64(8), 1998, pp. 748-751
Citations number
9
Language
INGLESE
art.tipo
Letter
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
0032-0943 → ACNP
Volume
64
Issue
8
Year of publication
1998
Pages
748 - 751
Database
ISI
SICI code
0032-0943(199812)64:8<748:SROPHA>2.0.ZU;2-M
Abstract
13-Alkyl derivatives (2-6 and 8-12) of berberine (1) and palmatine (7) were subjected to in vitro antibacterial activity tests against Bacillus subtil is and Solmonella enteritidis. Antibacterial activity increased as the leng th of the C-13 aliphatic side chain increased. The effects of the oxygen su bstituents on aromatic rings A, C, and D of protoberberinium salts 13-20 on the antimicrobial activity against Staphylococcus aureus, B. subtilis, S. enteritidis, Escherichia coil, and Candida albicans are also discussed. The change in lipophilicity of the protoberberinium salts caused by modificati on of the substituents appears to influence the antibacterial activity. 13- Hexylberberine (6) and 13-hexylpalmatine (12) exhibited the greatest antiba cterial activity.