Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins

Citation
K. Kimura et al., Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins, J ANTIBIOT, 51(12), 1998, pp. 1099-1104
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
0021-8820 → ACNP
Volume
51
Issue
12
Year of publication
1998
Pages
1099 - 1104
Database
ISI
SICI code
0021-8820(199812)51:12<1099:SIOTBP>2.0.ZU;2-I
Abstract
We examined the inhibitory activity against bacterial peptidoglycan biosynt hesis, mammalian glycoprotein biosynthesis and growth of BALB/3T3 cells of four different types of liposidomycins which have the structure with or wit hout sulfate and/or 3-methylglutaric acid moieties. Liposidomycins inhibite d peptidoglycan biosynthesis about 30 similar to 500 times more effectively than tunicamycin, whereas liposidomycins inhibited mammalian glycoprotein biosynthesis about 30 similar to 300 times less effectively than tunicamyci n. When the cytotoxic effect of liposidomycins and tunicamycin on the growt h of mammalian cells were compared, liposidomycins did not show toxicity ag ainst BALB/3T3 cell at 25 mu g/ml, though tunicamycin inhibited cell growth by 50% at 0.05 mu g/ml. On the basis of these results, it is concluded tha t liposidomycins are selective antibiotics showing highly specific inhibiti on toward bacterial peptidoglycan biosynthesis.