Morphometrical and immunopathological dissection of the hepatic Schistosoma haematobium granuloma in the murine host

Citation
W. Jacobs et al., Morphometrical and immunopathological dissection of the hepatic Schistosoma haematobium granuloma in the murine host, PARASITE, 5(4), 1998, pp. 299-306
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology
Journal title
PARASITE-JOURNAL DE LA SOCIETE FRANCAISE DE PARASITOLOGIE
ISSN journal
1252-607X → ACNP
Volume
5
Issue
4
Year of publication
1998
Pages
299 - 306
Database
ISI
SICI code
1252-607X(199812)5:4<299:MAIDOT>2.0.ZU;2-L
Abstract
This paper presents the results of a study aimed at identifying the immunop athological and morphometrical characteristics of liver granulomas induced by the parasite Schistosoma haematobium. The OF1 mouse is a susceptible hos t for experimental infection with the Egyptian NAMRU-3 strain of S. haemato bium. Formation of liver granulomas started after 13-14 weeks of infection. These hepatic granulomas reached a maximum volume after 20 weeks of infect ion (MGV: 1.82 +/- 0.15 x 10(7) mu m(3)) and regressed thereafter (1.55 +/- 0.16 x 10(7) mu m(3) after 24 weeks). Strong cellular upregulation of the adhesion molecules ICAM-1, LFA-1, syndecan-1, VLA-4, but not VLA-6 is seen, both in acute and chronic granulomas. Finally, pathological differences ex ist between hepatic S. mansoni and S. haematobium granulomas particularly a t the level of extracellular matrix deposition. S. haematobium induced peri -ovular deposition of mainly fibronectin and to a lesser extent type I and IV collagen.