Cloning and expression pattern of a murine semaphorin homologous to H-semaIV

Citation
F. Eckhardt et A. Meyerhans, Cloning and expression pattern of a murine semaphorin homologous to H-semaIV, NEUROREPORT, 9(17), 1998, pp. 3975-3979
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
9
Issue
17
Year of publication
1998
Pages
3975 - 3979
Database
ISI
SICI code
0959-4965(199812)9:17<3975:CAEPOA>2.0.ZU;2-1
Abstract
THE semaphorin/collapsin family of proteins comprises molecules thought to be important for the guidance of growing axons. All members of this family, which includes both secreted and cell-surface molecules, share a conserved domain of similar to 500 amino acids. Here, Ne report the cloning of a nov el murine semaphorin, termed M-sema IV. It displays 96.3% identity to the h uman semaphorin H-sema IV and is therefore likely to be the respective muri ne homologue. In addition, an isoform was identified, which contains an add itional 31 amino acids in the semaphorin domain. M-sema N appears to be exp ressed ubiquitously in adulthood. During embryogenesis, in situ hybridizati on revealed M-sema IV expression in subregions of the central nervous syste m and various other tissues like skin, kidney, lung and intestine. NeuroRep ort 9: 3975-3979 (C) 1998 Lippincott Williams & Wilkins.