Human developmental toxicity and mutagenesis

Citation
Hs. Rosenkranz et al., Human developmental toxicity and mutagenesis, MUT RES-F M, 422(2), 1998, pp. 347-350
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
ISSN journal
1386-1964 → ACNP
Volume
422
Issue
2
Year of publication
1998
Pages
347 - 350
Database
ISI
SICI code
1386-1964(199812)422:2<347:HDTAM>2.0.ZU;2-S
Abstract
A previously described SAR model of human developmental toxicity was analyz ed further. The model shows a number of mechanistic similarities with SAR m odels of other toxicological phenomena (systemic toxicity, chromosomal and genomic effects). This implies that there are many targets associated with developmental effects. Surprisingly the analyses revealed no significant me chanistic overlap between developmental toxicity in humans and mutagenicity in Salmonella, a surrogate for the occurrence of point mutations. Our stud y indicates that this lack of similarity is likely the result of the pre-sc reening strategies which largely eliminate Salmonella mutagens from among t he therapeutics introduced into human medicine. (C) 1998 Elsevier Science B .V. All rights reserved.