Immunoblastic lymphadenopathy-like T cell lymphoma evolving into a massiveplasma cell proliferation with biclonal paraproteinemia

Citation
T. Higuchi et al., Immunoblastic lymphadenopathy-like T cell lymphoma evolving into a massiveplasma cell proliferation with biclonal paraproteinemia, ACT HAEMAT, 100(3), 1998, pp. 151-155
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
ACTA HAEMATOLOGICA
ISSN journal
0001-5792 → ACNP
Volume
100
Issue
3
Year of publication
1998
Pages
151 - 155
Database
ISI
SICI code
0001-5792(1998)100:3<151:ILTCLE>2.0.ZU;2-7
Abstract
We present a case of immunoblastic lymphadenopathy-like T cell lymphoma (IB L-T) who subsequently developed a massive proliferation of plasma cells. At diagnosis of IBLT, the patient had polyclonal hypergammaglobulinemia and s ubsequently, while on chemotherapy, developed paraproteinemia with biclonal peaks and the IBLT lesion was replaced with a massive proliferation of CD3 8-positive plasma cells. The evolution was not likely to be attributed to a new neoplastic proliferation of B cells. It appeared that two B cell clone s possibly had a growth advantage among the polyclonal B cells due to a dep letion of suppressor T cells or to a disturbance in the immune system.