Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction

Citation
E. Koukkou et al., Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction, CIRCULATION, 98(25), 1998, pp. 2899-2904
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CIRCULATION
ISSN journal
0009-7322 → ACNP
Volume
98
Issue
25
Year of publication
1998
Pages
2899 - 2904
Database
ISI
SICI code
0009-7322(199812)98:25<2899:OONADR>2.0.ZU;2-Z
Abstract
Background-Disturbances of the in utero environment may "program" for disea se ill later life. In this study, we determined whether dietary fat supplem entation and/or diabetes in pregnancy can adversely affect vascular functio n in the offspring. Methods and Results-Female Sprague-Dawley rats were fed a breeding diet or a diet high in saturated fat (30% wt/wt) for 10 days before mating, through out pregnancy, and postpartum. Endothelium-dependent relaxation to acetylch oline was blunted in isolated femoral arteries of 15-day-old weanling pups from dams fed the 30%-fat diet. Endothelial dysfunction and enhanced constr ictor responses to norepinephrine were also observed in an additional study of 60-day-old offspring of dams fed 20% saturated fat. Rats with streptozo tocin-induced diabetes were also fed saturated fat during pregnancy, Femora l arteries from their 15-day-old offspring showed impairment of endothelium -dependent dilation and enhanced constrictor responses to norepinephrine an d the thromboxane mimetic U46619 compared with young offspring of high-fat- fed normal dams, The 30%-fat diet was also deleterious to vascular function in the maternal diabetic animals when assessed in mesenteric arteries 16 d ays postpartum, Conclusions-A high-fat diet in pregnancy led to vascular dysfunction in rat weanlings and young adult offspring. Vascular function further deteriorate d in weanlings if the maternal rat was diabetic.