Dupuytren's disease and frozen shoulder induced by treatment with a matrixmetalloproteinase inhibitor

Citation
Jw. Hutchinson et al., Dupuytren's disease and frozen shoulder induced by treatment with a matrixmetalloproteinase inhibitor, J BONE-BR V, 80B(5), 1998, pp. 907-908
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine","da verificare
Journal title
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
ISSN journal
0301-620X → ACNP
Volume
80B
Issue
5
Year of publication
1998
Pages
907 - 908
Database
ISI
SICI code
0301-620X(199809)80B:5<907:DDAFSI>2.0.ZU;2-0
Abstract
In a series of 12 patients with inoperable gastric carcinoma who had treatm ent with a synthetic matrix metalloproteinase inhibitor (Marimastat) for mo re than one month, six developed a frozen shoulder or a condition resemblin g Dupuytren's disease. This suggests that the matrix metalloproteinases, a family of naturally occ urring proteinases, may be involved in the pathogenesis of these two condit ions. Our observation opens avenues for further research which could lead t o local or systemic therapeutic interventions for frozen shoulder and Dupuy tren's disease.