In a series of 12 patients with inoperable gastric carcinoma who had treatm
ent with a synthetic matrix metalloproteinase inhibitor (Marimastat) for mo
re than one month, six developed a frozen shoulder or a condition resemblin
g Dupuytren's disease.
This suggests that the matrix metalloproteinases, a family of naturally occ
urring proteinases, may be involved in the pathogenesis of these two condit
ions. Our observation opens avenues for further research which could lead t
o local or systemic therapeutic interventions for frozen shoulder and Dupuy