CD40 regulation of death domains containing receptors and their ligands onlymphoma B cells

Citation
P. Ribeiro et al., CD40 regulation of death domains containing receptors and their ligands onlymphoma B cells, BR J HAEM, 103(3), 1998, pp. 684-689
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
0007-1048 → ACNP
Volume
103
Issue
3
Year of publication
1998
Pages
684 - 689
Database
ISI
SICI code
0007-1048(199812)103:3<684:CRODDC>2.0.ZU;2-T
Abstract
Within the tumour necrosis factor (TNF) family the induction of apoptosis i s restricted to some ligand-receptors pairs, including TNF-TNF receptor typ e I (TNFRI/p55). FasL-Fas, TNF-related apoptosis-inducing ligand (TRAIL) an d its death-receptors (DR)-4 and -5, The pair CD40L-CD40 belongs to the sam e family but rescues B cells from apoptosis. To investigate how these oppos ing actions are cross-linked, purified follicular lymphoma (FL) cells were activated upon a human CD40L-transfected murine fibroblastic layer, then RN A messengers for the above molecules were analysed using RT-PCR, The observ ed down-modulation of TRAIL and up-regulation of TNF and Fas transcripts mi ght account for CD40-CD40L-mediated FL cell survival.