Intracellular signaling from the endoplasmic reticulum to the nucleus

Citation
R. Chapman et al., Intracellular signaling from the endoplasmic reticulum to the nucleus, ANN R C DEV, 14, 1998, pp. 459-485
Citations number
74
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
14
Year of publication
1998
Pages
459 - 485
Database
ISI
SICI code
1081-0706(1998)14:<459:ISFTER>2.0.ZU;2-I
Abstract
Cells respond to an accumulation of unfolded proteins in the endoplasmic re ticulum (ER) by increasing transcription of genes encoding ER resident prot eins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway called the unfolded protein response (UPR) . Recent work has shown that this signaling pathway utilizes several novel mechanisms, including translational attenuation and a regulated mRNA splici ng step. In this review we aim to integrate these recent advances with curr ent knowledge about maintenance of ER composition and abundance.